Blar i forfatter "Wang, Qiang"

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    • Identification of a regulatory pathway governing TRAF1 via an arthritis-associated non-coding variant 

      Wang, Qiang; Martínez-Bonet, Marta; Kim, Taehyeung; Sparks, Jeffrey A.; Ishigaki, Kazuyoshi; Chen, Xiaoting; Sudman, Marc; Aguiar, Vitor; Sim, Sangwan; Hernandez, Marcos Chiñas; Chiu, Darren J.; Wactor, Alexandra; Wauford, Brian; Marion, Miranda C.; Gutierrez-Arcelus, Maria; Bowes, John; Eyre, Stephen; Nordal, Ellen Berit; Prahalad, Sampath; Rygg, Marite; Videm, Vibeke; Raychaudhuri, Soumya; Weirauch, Matthew T.; Langefeld, Carl D.; Thompson, Susan D.; Nigrovic, Peter A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-16)
      TRAF1/C5 was among the first loci shown to confer risk for inflammatory arthritis in the absence of an associated coding variant, but its genetic mechanism remains undefined. Using Immunochip data from 3,939 patients with juvenile idiopathic arthritis (JIA) and 14,412 control individuals, we identified 132 plausible common non-coding variants, reduced serially by single-nucleotide polymorphism ...

    • Properties and dynamics of mesoscale eddies in Fram Strait from a comparison between two high-resolution ocean-sea ice models 

      Wekerle, Claudia; Hattermann, Tore; Wang, Qiang; Crews, Laura; von Appen, Wilken-Jon; Danilov, Sergey (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-23)
      Fram Strait, the deepest gateway to the Arctic Ocean, is strongly influenced by eddy dynamics. Here we analyse the output from two eddy-resolving models (ROMS – Regional Ocean Modeling System; FESOM – Finite-Element Sea-ice Ocean Model) with around 1 km mesh resolution in Fram Strait, with a focus on their representation of eddy properties and dynamics. A comparison with mooring observations shows ...

    • Tracing Subducted Carbonates in Earth's Mantle Using Zinc and Molybdenum Isotopes 

      Wang, Jian; Tang, Gong-Jian; Tappe, Sebastian; Li, Jie; Zou, Zongqi; Wang, Qiang; Su, Yu-Ping; Zheng, Jian-Ping (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-23)
      Although carbonates are the primary form of carbon subducted into the mantle, their fate during recycling is debated. Here we report the first coupled high-precision Zn and Mo isotope data for Cenozoic intraplate basalts from western China. The exceptionally high δ<sup>66</sup>Zn values (+0.39 to +0.50‰) of these lavas require involvement of recycled carbonates in the mantle source. Variable ...